Protective effect of Actinidia arguta in MPTP-induced Parkinson’s disease model mice

Parkinson’s disease (PD) is a neurodegenerative characterized by the progressive degeneration of dopaminergic neurons in substantia nigra. Oxidative stress-induced neuronal death has been identified as one major causes nigrostriatal PD. The fruit Actinidia arguta (A. arguta), known sarunashi Japan, reported to show beneficial health effects such antioxidant, anti-inflammatory, anti-mutagenic, and anticholinergic effects. In this study, we investigated neuroprotective A. 1-methyl-4-phenyl-1,2,3,6-tetrahydropypridine (MPTP)-induced PD model mice. juice was administered 7-week-old C57BL/6J mice continuously for 10 days before first MPTP injection. nigra induced (30 mg/kg, i. p.) once daily five consecutive days. We found that administration ameliorated MPTP-induced motor impairment suppressed reductions tyrosine hydroxylase-positive hydroxylase protein expression Our findings suggest taking could provide neuroprotection delays or prevents process